Article
RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers.
Cancer research - 1 Jan 2008
Gao Boning, Xie Xian-Jin, Huang Chunxian, Shames David S, Chen Tina T-L, Lewis Cheryl M, Bian Aihua, Zhang Bifeng, Olopade Olufunmilayo I, Garber Judy E, Euhus David M, Tomlinson Gail E, Minna John D
Abstract excerpt
The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability and is inactivated by promoter methylation in approximately 50% of breast cancers. It has been shown previously that the polymorphism A133S in RASSF1A reduces its ability to regulate cell cycl...
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