Article
RASSF1A polymorphism A133S is associated with early onset breast cancer in BRCA1/2 mutation carriers.
Cancer research - 1 Jan 2008
Gao Boning, Xie Xian-Jin, Huang Chunxian, Shames David S, Chen Tina T-L, Lewis Cheryl M, Bian Aihua, Zhang Bifeng, Olopade Olufunmilayo I, Garber Judy E, Euhus David M, Tomlinson Gail E, Minna John D
Abstract excerpt
The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability and is inactivated by promoter methylation in approximately 50% of breast cancers. It has been shown previously that the polymorphism A133S in RASSF1A reduces its ability to regulate cell cycle progression and this polymorphism is associated with an increased risk of breast cancer. We analyzed the frequency of...
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