Article
No association of TGFB1 L10P genotypes and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a multi-center cohort study.
Breast cancer research and treatment - 1 May 2009
Rebbeck Timothy R, Antoniou Antonis C, Llopis Trinidad Caldes, Nevanlinna Heli, Aittomäki Kristiina, Simard Jacques, Spurdle Amanda B, Couch Fergus J, Pereira Lutecia H Mateus, Greene Mark H, Andrulis Irene L, Pasche Boris, Kaklamani Virginia, Hamann Ute, Szabo Csilla, Peock Susan, Cook Margaret, Harrington Patricia A, Donaldson Alan, Male Allison M, Gardiner Carol Anne, Gregory Helen, Side Lucy E, Robinson Anne C, Emmerson Louise, Ellis Ian, Peyrat Jean-Philippe, Fournier Joëlle, Vennin Philippe, Adenis Claude, Muller Danièle, Fricker Jean-Pierre, Longy Michel, Sinilnikova Olga M, Stoppa-Lyonnet Dominique, Schmutzler Rita K, Versmold Beatrix, Engel Christoph, Meindl Alfons, Kast Karin, Schaefer Dieter, Froster Ursula G, Chenevix-Trench Georgia, Easton Douglas F
Abstract excerpt
BACKGROUND: The transforming growth factor beta-1 gene (TGFB1) is a plausible candidate for breast cancer susceptibility. The L10P variant of TGFB1 is associated with higher circulating levels and secretion of TGF-beta, and recent large-scale studies suggest strongly that this variant is associated with breast cancer risk in the general population. METHODS: To evaluate whether TGFB1 L10P also modifies the risk of...
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