Article
Exome sequencing identifies RASSF1 and KLK3 germline variants in an Iranian multiple-case breast cancer family.
European journal of medical genetics - 1 Mar 2022
Radmanesh Hoda, Liu Di, Geffers Robert, Shandiz Fatemeh Homaei, Sadr-Nabavi Ariane, Hillemanns Peter, Park-Simon Tjoung-Won, Dörk Thilo
Abstract excerpt
Breast cancer is the most frequent malignancy among women in both developed and developing countries. Although several genes have been identified to harbor germline variants contributing to breast cancer risk, much of the heritability for breast cancer is yet undefined. In the present study, we have performed exome sequencing to detect susceptibility genes in an Iranian family with five first-degree family...
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