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Article

Clinical characteristics of semantic variant of primary progressive aphasia with TDP-43- and tau-related gene variants.

Journal of Alzheimer's disease : JAD - 1 Feb 2025

Ma Yayu, Tang Chao, Lei Xiaoyang, Wang Li, He Dian

Abstract excerpt

BACKGROUND: Semantic variant primary progressive aphasia (svPPA) can be inheritable. There is a predictable relationship between the pathological substrate and genetic variants in this condition. OBJECTIVE: To report a case with svPPA who carried a MAPT gene mutation and to explore clinical differences between svPPA with TDP-43 pathology-related genes and svPPA with tau pathology-related genes. METHODS: Studies...

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Source

Identifiers

PMID: 39924821
DOI: 10.1177/13872877241312932

Genes

MAPT
TARDBP
GRN
TBK1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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