Article
Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection.
Nature genetics - 1 Jan 2006
Chan Vera S F, Chan Kelvin Y K, Chen Yongxiong, Poon Leo L M, Cheung Annie N Y, Zheng Bojian, Chan Kwok-Hung, Mak William, Ngan Hextan Y S, Xu Xiaoning, Screaton Gavin, Tam Paul K H, Austyn Jonathan M, Chan Li-Chong, Yip Shea-Ping, Peiris Malik, Khoo Ui-Soon, Lin Chen-Lung S
Abstract excerpt
Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to...
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