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Article

FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase.

The Journal of biological chemistry - 11 Jun 2010

Guignard Thomas J P, Jin Minghao, Pequignot Marie O, Li Songhua, Chassigneux Yolaine, Chekroud Karim, Guillou Laurent, Richard Eric, Hamel Christian P, Brabet Philippe

Abstract excerpt

The isomerization of all-trans retinol (vitamin A) to 11-cis retinol in the retinal pigment epithelium (RPE) is a key step in the visual process for the regeneration of the visual pigment chromophore, 11-cis retinal. LRAT and RPE65 are recognized as the minimal isomerase catalytic components. However, regulators of this rate-limiting step are not fully identified and could account for the phenotypic variability...

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Source

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Identifiers

PMID: 20356843
DOI: 10.1074/jbc.M109.064329
PMCID: PMC2881799

Genes

RPE65
RPE
LRAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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