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Article

Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A.

The Journal of biological chemistry - 28 May 2010

Playford Martin P, Nurminen Elisa, Pentikäinen Olli T, Milgram Sharon L, Hartwig John H, Stossel Thomas P, Nakamura Fumihiko

Abstract excerpt

Mutations of the chloride channel cystic fibrosis transmembrane conductance regulator (CFTR) that impair its apical localization and function cause cystic fibrosis. A previous report has shown that filamin A (FLNa), an actin-cross-linking and -scaffolding protein, interacts directly with the cytoplasmic N terminus of CFTR and that this interaction is necessary for stability and confinement of the channel to...

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Identifiers

PMID: 20351098
DOI: 10.1074/jbc.M109.080523
PMCID: PMC2878090

Genes

CFTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A.PMID 20351098Read ↗

Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin.Semantic proximity Read ↗

Direct interaction with filamins modulates the stability and plasma membrane expression of CFTRSemantic proximity Read ↗

Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.Semantic proximity Read ↗

Interaction of Filamin C With Actin Is Essential for Cardiac Development and Function.Semantic proximity Read ↗

Multiple Membrane-Cytoplasmic Domain Contacts in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mediate Regulation of Channel GatingSemantic proximity Read ↗

CFTR processing, trafficking and interactions.Semantic proximity Read ↗

Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens.Semantic proximity Read ↗

Crystal structure of the dimerization domain of human filamin ASemantic proximity Read ↗

Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders†Semantic proximity Read ↗

Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation.Semantic proximity Read ↗

Protein interactions, calcium, phosphorylation, and cholesterol modulate CFTR cluster formation on membranesSemantic proximity Read ↗

CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.Semantic proximity Read ↗

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