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Article

CFTR processing, trafficking and interactions.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Mar 2020

Amaral Margarida D, Hutt Darren M, Tomati Valeria, Botelho Hugo M, Pedemonte Nicoletta

Abstract excerpt

Mutations associated with cystic fibrosis (CF) have complex effects on the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common CF mutation, F508del, disrupts the processing to and stability at the plasma membrane and function as a Cl- channel. CFTR is surrounded by a dynamic network of interacting components, referred to as the CFTR Functional Landscape, that impact its synthesis,...

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Identifiers

PMID: 31680043
DOI: 10.1016/j.jcf.2019.10.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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