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Structure of filamin A immunoglobulin-like repeat 10 from Homo sapiens.

Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Aug 2011

Page Richard C, Clark Jeffrey G, Misra Saurav

Abstract excerpt

Filamin A (FlnA) plays a critical role in cytoskeletal organization, cell motility and cellular signaling. FlnA utilizes different binding sites on a series of 24 immunoglobulin-like domains (Ig repeats) to interact with diverse cytosolic proteins and with cytoplasmic portions of membrane proteins. Mutations in a specific domain, Ig10 (FlnA-Ig10), are correlated with two severe forms of the otopalatodigital...

Topics

Contractile Proteins
Filamins
Humans
Immunoglobulins
Microfilament Proteins
Models, Molecular
Mutation
Protein Structure, Tertiary
Repetitive Sequences, Amino Acid

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Identifiers

PMID: 21821884
DOI: 10.1107/S1744309111024249
PMCID: PMC3151117

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