Article
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.
Molecular systems biology - 1 Feb 2022
Lim Sang Hyun, Snider Jamie, Birimberg-Schwartz Liron, Ip Wan, Serralha Joana C, Botelho Hugo M, Lopes-Pacheco Miquéias, Pinto Madalena C, Moutaoufik Mohamed Taha, Zilocchi Mara, Laselva Onofrio, Esmaeili Mohsen, Kotlyar Max, Lyakisheva Anna, Tang Priscilla, López Vázquez Lucía, Akula Indira, Aboualizadeh Farzaneh, Wong Victoria, Grozavu Ingrid, Opacak-Bernardi Teuta, Yao Zhong, Mendoza Meg, Babu Mohan, Jurisica Igor, Gonska Tanja, Bear Christine E, Amaral Margarida D, Stagljar Igor
Abstract excerpt
Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is a chloride and bicarbonate channel in secretory epithelia with a critical role in maintaining fluid homeostasis. Mutations in CFTR are associated with Cystic Fibrosis (CF), the most common lethal autosomal recessive disorder in Caucasians. While remarkable treatment advances have been made recently in the form of modulator drugs directly rescuing CFTR...
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