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Article

Heme Oxygenase-1-Expressing Dendritic Cells Promote Foxp3+ Regulatory T Cell Differentiation and Induce Less Severe Airway Inflammation in Murine Models.

PloS one - 1 Jan 2016

Wong Tzu-Hsuan, Chen Hung-An, Gau Rung-Jiun, Yen Jeng-Hsien, Suen Jau-Ling

Abstract excerpt

Dendritic cells (DCs) are critical for instructing immune responses toward inflammatory or anti-inflammatory status. Heme oxygenase-1 (HO-1) is known for its cytoprotective effect against oxidative stress and inflammation, suggesting its immune regulatory role in allergic lung inflammation. HO-1 has been implicated in affecting DC maturation; however, its role in DC-mediated T-cell differentiation is unclear. In...

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PMID: 28033400
DOI: 10.1371/journal.pone.0168919
PMCID: PMC5199094

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