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Article

Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.

Proceedings of the National Academy of Sciences of the United States of America - 29 Aug 1995

Yamanaka S, Balestra M E, Ferrell L D, Fan J, Arnold K S, Taylor S, Taylor J M, Innerarity T L

Abstract excerpt

Apolipoprotein (apo-) B mRNA editing is the deamination of cytidine that creates a new termination codon and produces a truncated version of apo-B (apo-B48). The cytidine deaminase catalytic subunit [apo-B mRNA-editing enzyme catalytic polypeptide 1 (APOBEC-1)] of the multiprotein editing complex has been identified. We generated transgenic rabbits and mice expressing rabbit APOBEC-1 in their livers to determine...

Topics

APOBEC-1 Deaminase
Animals
Animals, Genetically Modified
Base Sequence
Cytidine Deaminase
DNA Primers
Liver
Liver Neoplasms, Experimental
Mice
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA Processing, Post-Transcriptional

RNA, Messenger

Rabbits

AICDA (Activation-Induced Cytidine Deaminase)

Source

Open in PubMed Open full text

Identifiers

PMID: 7667315
DOI: 10.1073/pnas.92.18.8483
PMCID: PMC41181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7667315-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals.PMID 7667315Read ↗

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