Article

Microglia maintain retinal redox homeostasis following ablation of rod photoreceptors in zebrafish

2025-10-19

Abstract excerpt

Microglia rapidly respond to injury, stress, and perturbations to neurons in the brain and retina and perform phagocytosis to clear dying cells and debris. Oxidative stress is a frequent feature of neurodegeneration, and while glia are crucial for managing such stress, microglia may also be dysfunctional in diseased tissue. Here we examine the role of microglia in management of oxidative stress upon death of rod p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 58350508-997c-5b9d-9168-d5d9be28c499
DOI: 10.1101/2025.10.17.683173

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microglia maintain retinal redox homeostasis following ablation of rod photoreceptors in zebrafishDOI 10.1101/2025.10.17.683173Read

Photoreceptor regeneration occurs normally in microglia-deficient irf8 mutant zebrafish following acute retinal damage.Semantic proximity Read

A Dynamic Change of Microglial States Occurs During the Transition From Photoreceptor Degeneration to Regeneration in Zebrafish pde6c Mutants.Semantic proximity Read

Cytokines IL-1β and IL-10 are required for Müller glia proliferation following light damage in the adult zebrafish retinaSemantic proximity Read

Cellular and molecular alterations in neurons and glial cells in inherited retinal degenerationSemantic proximity Read

Single Cell RNA Sequencing Analysis of Mouse Retina Identifies a Subpopulation of Muller Glia Involved in Retinal Recovery From Injury in the FCD-LIRD ModelSemantic proximity Read

Role of microglial cells in photoreceptor degenerationSemantic proximity Read

The immune response is a critical regulator of zebrafish retinal pigment epithelium regeneration.Semantic proximity Read

More than meets the eye: The role of microglia in healthy and diseased retinaSemantic proximity Read

Notch inhibition promotes regeneration and immunosuppression supports cone survival in a zebrafish model of inherited retinal dystrophySemantic proximity Read

Retinal scRNAseq reveals cell-type-specific responses to bacterial infectionSemantic proximity Read

Regeneration associated transcriptional signature of retinal microglia and macrophagesSemantic proximity Read

A possible mechanism of microglia-photoreceptor crosstalk.Semantic proximity Read