Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells.

Free radical research - 1 Dec 2005

Nikolova Sevdalina, Lee Yong Soo, Lee Yoon-Seok, Kim Jung-Ae

Abstract excerpt

Reactive oxygen species (ROS) are known to play an important role in glutamate-induced neuronal cell death. In the present study, we examined whether NADPH oxidase serves as a source of ROS production and plays a role in glutamate-induced cell death in SH-SY5Y human neuroblastoma cells. Stimulation of the cells with glutamate (100 mM) induced apoptotic cell death and increase in the level of ROS, and these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Membrane
Share to Glutamic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NADPH Oxidases

Share to Neurons

Share to Protein Transport

Share to rac1 GTP-Binding Protein

Share to Reactive Oxygen Species

Source

Identifiers

PMID: 16298859
DOI: 10.1080/10715760500176866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rac1-NADPH oxidase-regulated generation of reactive oxygen species mediates glutamate-induced apoptosis in SH-SY5Y human neuroblastoma cells.PMID 16298859Read ↗

NOX2-Derived Hydrogen Peroxide Impedes the AMPK/Akt-mTOR Signaling Pathway in Parkinson's Disease in Vitro ModelsSemantic proximity Read ↗

A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics.Semantic proximity Read ↗

Fluorescent Analysis Reveals that Insulin Diminishes Superoxide Increase in Neurons Induced with Toxic Glutamate TreatmentSemantic proximity Read ↗

Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death.Semantic proximity Read ↗

Alsin and SOD1(G93A) proteins regulate endosomal reactive oxygen species production by glial cells and proinflammatory pathways responsible for neurotoxicity.Semantic proximity Read ↗

Tanshinone IIA Inhibits Glutamate‐Induced Oxidative Toxicity through Prevention of Mitochondrial Dysfunction and Suppression of MAPK Activation in SH‐SY5Y Human Neuroblastoma CellsSemantic proximity Read ↗

Reactive Oxygen Species (ROS), Reactive Nitrogen Species (RNS), Antioxidants, and Cerebral Vascular ToneSemantic proximity Read ↗

NOX Activation by Subunit Interaction and Underlying Mechanisms in DiseaseSemantic proximity Read ↗

NADPH oxidase and extracellular regulated kinases 1/2 are targets of prion protein signaling in neuronal and nonneuronal cells.Semantic proximity Read ↗

A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death.Semantic proximity Read ↗

Presenilin-1-deficient neurons are nitric oxide-dependently killed by hydrogen peroxide in vitro.Semantic proximity Read ↗

Reduced mitochondrial complex II activity enhances cell death via intracellular reactive oxygen species in STHdhQ111 striatal neurons with mutant huntingtin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.