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Article

Proteinase K-resistant alpha-synuclein is deposited in presynapses in human Lewy body disease and A53T alpha-synuclein transgenic mice.

Acta neuropathologica - 1 Aug 2010

Tanji Kunikazu, Mori Fumiaki, Mimura Junsei, Itoh Ken, Kakita Akiyoshi, Takahashi Hitoshi, Wakabayashi Koichi

Abstract excerpt

Abnormally modified alpha-synuclein is a pathological hallmark of Parkinson's disease and the other alpha-synucleinopathies. Since proteinase K (PK) treatment is known to enhance the immunoreactivity of abnormal alpha-synuclein, we immunohistochemically examined the brain of transgenic (Tg) mice expressing human mutant A53T alpha-synuclein using this retrieval method. PK treatment abolished the immunoreactivity...

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PMID: 20339856
DOI: 10.1007/s00401-010-0676-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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