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Article

Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 2009

Yen Hui-Ling, Aldridge Jerry R, Boon Adrianus C M, Ilyushina Natalia A, Salomon Rachelle, Hulse-Post Diane J, Marjuki Henju, Franks John, Boltz David A, Bush Dorothy, Lipatov Aleksandr S, Webby Richard J, Rehg Jerold E, Webster Robert G

Abstract excerpt

The HA of influenza virus is a receptor-binding and fusion protein that is required to initiate infection. The HA receptor-binding domain determines the species of sialyl receptors recognized by influenza viruses. Here, we demonstrate that changes in the HA receptor-binding domain alter the ability of the H5N1 virus to spread systemically in mice. The A/Vietnam/1203/04 (VN1203) and A/Hong Kong/213/03 (HK213)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

Share to Influenza A Virus, H5N1 Subtype

Share to Neuraminidase

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Identifiers

PMID: 19116267
DOI: 10.1073/pnas.0811052106
PMCID: PMC2629220

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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