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Article

Hemagglutinin mutations related to attenuation and altered cell tropism of a virulent avian influenza A virus.

Journal of virology - 1 Jun 1990

Philpott M, Hioe C, Sheerar M, Hinshaw V S

Abstract excerpt

The H5 hemagglutinin (HA) of a highly virulent avian influenza virus, A/Turkey Ontario/7732/66 (H5N9), was previously shown to have five neutralizing epitopes, and escape mutants within one epitope (group 1) were markedly attenuated (M. Philpott, B. C. Easterday, and V. S. Hinshaw, J. Virol. 63:3453-3458, 1989). To define the genetic changes related to these antigenic and biologic properties, the HA genes of...

Topics

Amino Acid Sequence
Animals
Base Sequence
Chick Embryo
Chickens
Cloning, Molecular
DNA, Viral
Hemagglutinins, Viral
Influenza A virus
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Spleen

Virulence

Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 2335822
DOI: 10.1128/JVI.64.6.2941-2947.1990
PMCID: PMC249478

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2335822-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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