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Article

Hemagglutinin mutations related to attenuation and altered cell tropism of a virulent avian influenza A virus.

Journal of virology - 1 Jun 1990

Philpott M, Hioe C, Sheerar M, Hinshaw V S

Abstract excerpt

The H5 hemagglutinin (HA) of a highly virulent avian influenza virus, A/Turkey Ontario/7732/66 (H5N9), was previously shown to have five neutralizing epitopes, and escape mutants within one epitope (group 1) were markedly attenuated (M. Philpott, B. C. Easterday, and V. S. Hinshaw, J. Virol. 63:3453-3458, 1989). To define the genetic changes related to these antigenic and biologic properties, the HA genes of...

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Identifiers

PMID: 2335822
DOI: 10.1128/JVI.64.6.2941-2947.1990
PMCID: PMC249478

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