Article
Impact of highly conserved HLA haplotype on acute graft-versus-host disease.
Blood - 10 Jun 2010
Morishima Satoko, Ogawa Seishi, Matsubara Aiko, Kawase Takakazu, Nannya Yasuhito, Kashiwase Koichi, Satake Masahiro, Saji Hiroo, Inoko Hidetoshi, Kato Shunichi, Kodera Yoshihisa, Sasazuki Takehiko, Morishima Yasuo
Abstract excerpt
Although the effects of human leukocyte antigen (HLA) locus matching on clinical outcome in unrelated hematopoietic stem cell transplantations have been characterized, the biologic implications of HLA haplotypes have not been defined. We demonstrated the genetic fixity of Japanese conserved extended haplotypes by multi-single nucleotide polymorphism analysis in 1810 Japanese donor-recipient pairs matching with...
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