High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program.

doi:10.1371/journal.pone.0139485

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High-Resolution Analyses of Human Leukocyte Antigens Allele and Haplotype Frequencies Based on 169,995 Volunteers from the China Bone Marrow Donor Registry Program.

PloS one - 1 Jan 2015

Zhou Xiao-Yang, Zhu Fa-Ming, Li Jian-Ping, Mao Wei, Zhang De-Mei, Liu Meng-Li, Hei Ai-Lian, Dai Da-Peng, Jiang Ping, Shan Xiao-Yan, Zhang Bo-Wei, Zhu Chuan-Fu, Shen Jie, Deng Zhi-Hui, Wang Zheng-Lei, Yu Wei-Jian, Chen Qiang, Qiao Yan-Hui, Zhu Xiang-Ming, Lv Rong, Li Guo-Ying, Li Guo-Liang, Li Heng-Cong, Zhang Xu, Pei Bin, Jiao Li-Xin, Shen Gang, Liu Ying, Feng Zhi-Hui, Su Yu-Ping, Xu Zhao-Xia, Di Wen-Ying, Jiang Yao-Qin, Fu Hong-Lei, Liu Xiang-Jun, Liu Xiang, Zhou Mei-Zhen, Du Dan, Liu Qi, Han Ying, Zhang Zhi-Xin, Cai Jian-Ping

Abstract excerpt

Allogeneic hematopoietic stem cell transplantation is a widely used and effective therapy for hematopoietic malignant diseases and numerous other disorders. High-resolution human leukocyte antigen (HLA) haplotype frequency distributions not only facilitate individual donor searches but also determine the probability with which a particular patient can find HLA-matched donors in a registry. The frequencies of the...

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PMID: 26421847
DOI: 10.1371/journal.pone.0139485
PMCID: PMC4589403

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