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Article

HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2010

Aiello Aurora, Pandini Giuseppe, Sarfstein Rive, Werner Haim, Manfioletti Guidalberto, Vigneri Riccardo, Belfiore Antonino

Abstract excerpt

The IGF-I receptor (IGF-IR) is often overexpressed in cancer and is believed to play a crucial role in cancer progression. High Mobility Group A1 (HMGA1) is a non-histone chromatin protein that has the ability to regulate gene expression through DNA binding and involvement in enhanceosome complexes. HMGA1 is expressed at low level in adult differentiated cells, whereas it is expressed at high level in embryonic...

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Source

Identifiers

PMID: 20335021
DOI: 10.1016/j.ejca.2010.02.050

Genes

HMGA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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