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Article

Control of methionine biosynthesis in Escherichia coli K12: a closer study with analogue-resistant mutants.

Journal of general microbiology - 1 Mar 1991

Chattopadhyay M K, Ghosh A K, Sengupta S

Abstract excerpt

Control of methionine biosynthesis in Escherichia coli K12 was reinvestigated by using methionine-analogue-resistant mutants. Norleucine (NL) and alpha-methylmethionine (MM) were found to inhibit methionine biosynthesis directly whereas ethionine (Et) competitively inhibited methionine utilization. Adenosylation of Et to generate S-adenosylethionine (AdoEt) by cell-free enzyme from E. coli K12 was demonstrated....

Topics

Adenosine
Amino Acids
Chromosome Mapping
Chromosomes, Bacterial
Drug Resistance, Microbial
Escherichia coli
Ethionine
Genotype
Kinetics
Methionine
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Norleucine

Phenotype

Transformation, Bacterial

Source

Identifiers

PMID: 2033383
DOI: 10.1099/00221287-137-3-685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2033383-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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