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Article

Epistasis between APOE and nicotinic receptor gene CHRNA4 in age related cognitive function and decline.

Journal of the International Neuropsychological Society : JINS - 1 May 2010

Reinvang Ivar, Lundervold Astri J, Wehling Eike, Rootwelt Helge, Espeseth Thomas

Abstract excerpt

Healthy participants (n = 237) aged 45-79 were tested neuropsychologically with tests of memory, speed, and cognitive control and followed up for 3-5 years (mean, 3.4 years). The sample was genotyped for apolipoprotein E (APOE) and CHolinergic Receptor for Nicotine Alpha 4 (CHRNA4), and genetic effects on cognitive function at initial testing and on cognitive decline was studied. We predicted relatively stronger...

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Source

Identifiers

PMID: 20331911
DOI: 10.1017/S1355617710000263

Genes

APOE
CHRNA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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