Article
TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.
World journal of gastroenterology - 28 Sept 2015
Volodko Natalia, Salla Mohamed, Eksteen Bertus, Fedorak Richard N, Huynh Hien Q, Baksh Shairaz
Abstract excerpt
AIM: To investigate the association between tumor protein 53 (TP53) codon 72 polymorphisms and the risk for inflammatory bowel disease (IBD) development. METHODS: Numerous genetic and epigenetic drivers have been identified for IBD including the TP53 gene. Pathogenic mutations in TP53 gene have only been reported in 50% of colorectal cancer (CRC) patients. A single nucleotide polymorphism (SNP) in the TP53 gene...
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