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Arg72Pro polymorphism of p53 may predict poor response to medical treatment in ulcerative colitis.

Annali italiani di chirurgia - 1 Jan 2000

Vietri Maria Teresa, Riegler Gabriele, Pellino Gianluca, Molinari Anna Maria, Cioffi Michele

Abstract excerpt

AIM: Arg72Pro is a polymorphism commonly occurring in the proline-rich domain of Tp53. It can determine the development of different types of cancers, such as breast, lung, cervical, colorectal and hepatocellular carcinoma. Previous studies reported a correlation between Pro72 homozygosity and the clinical course of ulcerative colitis (UC). Our aim was to evaluate Arg72Pro genotype in patients who underwent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25712892

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