Article

The structural diversity of telomeres and centromeres across mouse subspecies revealed by complete assemblies

2024-10-24

Abstract excerpt

It is over twenty years since the publication of the C57BL/6J mouse reference genome, which has been a key catalyst for understanding mammalian disease biology. However, the mouse reference genome still lacks telomeres and centromeres, contains 281 chromosomal sequence gaps, and only partially represents many biomedically relevant loci. We present the first T2T mouse genomes for two key inbred strains, C57BL/6J an...

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Literature Corpus work: 5919b620-02da-547b-bbb9-c14d80e9245f
DOI: 10.1101/2024.10.24.619615

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