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Article

Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727.

Journal of bacteriology - 1 Aug 2015

Lo Grasso Letizia, Maffioli Sonia, Sosio Margherita, Bibb Mervyn, Puglia Anna Maria, Alduina Rosa

Abstract excerpt

UNLABELLED: The actinomycete Nonomuraea sp. strain ATCC 39727 produces the glycopeptide A40926, the precursor of dalbavancin. Biosynthesis of A40926 is encoded by the dbv gene cluster, which contains 37 protein-coding sequences that participate in antibiotic biosynthesis, regulation, immunity, and export. In addition to the positive regulatory protein Dbv4, the A40926-biosynthetic gene cluster encodes two...

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Identifiers

PMID: 25986904
DOI: 10.1128/JB.00262-15
PMCID: PMC4518825

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Two Master Switch Regulators Trigger A40926 Biosynthesis in Nonomuraea sp. Strain ATCC 39727.PMID 25986904Read ↗

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