Article
Molecular and structural effects of inverse agonistic mutations on signaling of the thyrotropin receptor--a basally active GPCR.
Cellular and molecular life sciences : CMLS - 1 Nov 2008
Kleinau G, Jaeschke H, Mueller S, Worth C L, Paschke R, Krause G
Abstract excerpt
Several mutations that decrease the basal signaling activity of G-protein coupled receptors (GPCRs) with pathogenic implications are known. Here we study the molecular mechanisms responsible for this phenotype and investigate how basal and further activated receptor conformations are interrelated...
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