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Article

beta-Catenin functions mainly as an adhesion molecule in patients with squamous cell cancer of the head and neck.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Apr 2005

Yu Ziwei, Weinberger Paul M, Provost Elayne, Haffty Bruce G, Sasaki Clarence, Joe J, Camp R L, Rimm D L, Psyrri Amanda

Abstract excerpt

BACKGROUND: beta-catenin, depending on subcellular localization, plays a dual role in carcinogenesis: as a signaling factor (in the nucleus) and as an adhesion molecule (in cell membrane). In this study, we sought to determine the role of beta-catenin in head and neck carcinogenesis. METHODS: First, we studied the incidence of mutations of beta-catenin in a cohort of 60 head and neck squamous cell cancers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15814622
DOI: 10.1158/1078-0432.CCR-04-2199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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