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Article

Novel avermectins produced by mutational biosynthesis.

The Journal of antibiotics - 1 Mar 1991

Dutton C J, Gibson S P, Goudie A C, Holdom K S, Pacey M S, Ruddock J C, Bu'Lock J D, Richards M K

Abstract excerpt

Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins...

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Source

Identifiers

PMID: 2026561
DOI: 10.7164/antibiotics.44.357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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