Article
Novel avermectins produced by mutational biosynthesis.
The Journal of antibiotics - 1 Mar 1991
Dutton C J, Gibson S P, Goudie A C, Holdom K S, Pacey M S, Ruddock J C, Bu'Lock J D, Richards M K
Abstract excerpt
Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins...
Topics
- Animals
- Anthelmintics
- Caenorhabditis
- Carboxylic Acids
- Chromatography, High Pressure Liquid
- Diptera
- Fermentation
- Ivermectin
- Molecular Structure
- Mutation
- Streptomyces