Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis.

doi:10.7164/antibiotics.48.59

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Article

Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis.

The Journal of antibiotics - 1 Jan 1995

Pang C H, Matsuzaki K, Ikeda H, Tanaka H, Omura S

Abstract excerpt

Streptomyces avermitilis produces the anthelmintic and insecticidal secondary metabolite avermectins. Following mutagenesis of a recombinant strain, S. avermitilis K2038 (aveD X) with N-methyl-N'-nitro-N-nitrosoguanidine, a derivative strain K2057 (aveD aveE X), was isolated, which produced seven...

Topics

Anthelmintics
Antiprotozoal Agents
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Cloning, Molecular
DNA, Bacterial
Genes, Bacterial
Ivermectin
Mutagenesis
Mutation
Streptomyces

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