Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity.

The Journal of antibiotics - 1 Mar 1991

Hafner E W, Holley B W, Holdom K S, Lee S E, Wax R G, Beck D, McArthur H A, Wernau W C

Abstract excerpt

The eight natural avermectins produced by Streptomyces avermitilis have the carbon skeleton of either isobutyric or S-2-methylbutyric acid incorporated into their structures. A mutant of S. avermitilis has been isolated that contains no functional branched-chain 2-oxo acid dehydrogenase activity. The mutant, in contrast to its parent, is unable to grow with isoleucine, valine and leucine as carbon sources. In...

Topics

3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide)
Anthelmintics
Chromatography, High Pressure Liquid
Culture Media
Fatty Acids
Fermentation
Ivermectin
Ketone Oxidoreductases
Multienzyme Complexes
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Streptomyces

Source

Identifiers

PMID: 2026560
DOI: 10.7164/antibiotics.44.349

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2026560-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Branched-chain fatty acid requirement for avermectin production by a mutant of Streptomyces avermitilis lacking branched-chain 2-oxo acid dehydrogenase activity.PMID 2026560Read ↗

Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis.Semantic proximity Read ↗

A second branched-chain alpha-keto acid dehydrogenase gene cluster (bkdFGH) from Streptomyces avermitilis: its relationship to avermectin biosynthesis and the construction of a bkdF mutant suitable for the production of novel antiparasitic avermectins.Semantic proximity Read ↗

Novel avermectins produced by mutational biosynthesis.Semantic proximity Read ↗

Control of avermectin biosynthesis in Streptomyces avermitilis for the selective production of a useful component.Semantic proximity Read ↗

Production of 6,8a-seco-6,8a-deoxy derivatives of avermectins by a mutant strain of Streptomyces avermitilis.Semantic proximity Read ↗

Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains.Semantic proximity Read ↗

Branched-chain fatty acid biosynthesis in a branched-chain amino acid aminotransferase mutant of Staphylococcus carnosus.Semantic proximity Read ↗

The pathway-specific regulator AveR from Streptomyces avermitilis positively regulates avermectin production while it negatively affects oligomycin biosynthesisSemantic proximity Read ↗

Organization of biosynthetic gene cluster for avermectin in Streptomyces avermitilis : analysis of enzymatic domains in four polyketide synthasesSemantic proximity Read ↗

Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilisSemantic proximity Read ↗

Branched-chain fatty acids produced by mutants of Streptomyces fradiae, putative precursors of the lactone ring of tylosin.Semantic proximity Read ↗

Catalytic domain of AfsKav modulates both secondary metabolism and morphologic differentiation in Streptomyces avermitilis ATCC 31272.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.