Article
HLA-DR1 and rheumatoid arthritis in Israeli Jews: sequencing reveals that DRB1*0102 is the predominant HLA-DR1 subtype.
Tissue antigens - 1 Jan 1993
de Vries N, Rønningen K S, Tilanus M G, Bouwens-Rombouts A, Segal R, Egeland T, Thorsby E, van de Putte L B, Brautbar C
Abstract excerpt
Rheumatoid arthritis (RA) is associated with the HLA-DR4 cellular subtypes Dw4 and Dw14 in Caucasians, with Dw15 in Japanese, and possibly with HLA-DR1 in Israeli Jews. Sequencing studies in Caucasians have shown that these molecules share a common amino acid sequence in the third hypervariable r...
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Rheumatoid
- Autoimmune Diseases
- Disease Susceptibility
- Female
- Genetic Predisposition to Disease
- HLA-DR Antigens
- HLA-DRB1 Chains
- Haplotypes
- Histocompatibility Antigens Class II
- Humans
- Israel
- Jews
- Male