Article
HLA-DR genotypes in familial rheumatoid arthritis: increased frequency of protective and neutral alleles in a multicase family.
The Journal of rheumatology - 1 Dec 2005
Zsilák Szilvia, Gál János, Hodinka László, Rajczy Katalin, Balog Attila, Sipka Sándor, Baráth Sándor, Kapitány Anikó, Zilahi Erika, Szekanecz Zoltán
Abstract excerpt
OBJECTIVE: We describe a unique family where each of the 5 siblings in the second generation has rheumatoid arthritis (RA). Two other members of the family have RA and systemic lupus erythematosus (SLE), respectively. No members of previous generations in the family had documented inflammatory arthritis. Due to the suspected genetic predisposition, HLA-DR genotypes were determined in the affected siblings and...
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