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Article

Proteomic and genomic biomarkers for age-related macular degeneration.

Advances in experimental medicine and biology - 1 Jan 2010

Gu Jiayin, Pauer Gayle J T, Yue Xiuzhen, Narendra Umadevi, Sturgill Gwen M, Bena James, Gu Xiaorong, Peachey Neal S, Salomon Robert G, Hagstrom Stephanie A, Crabb John W

Abstract excerpt

Toward early detection of susceptibility to age-related macular degeneration (AMD), we quantified plasma carboxyethylpyrrole (CEP) oxidative protein modifications and CEP autoantibodies by ELISA in 916 AMD and 488 control donors. Mean CEP adduct and autoantibody levels were elevated in AMD plasma by ∼60 and ∼30%, respectively, and the odds ratio for both CEP markers elevated was ∼3-fold greater in AMD than in...

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Source

Identifiers

PMID: 20238042
DOI: 10.1007/978-1-4419-1399-9_47

Genes

ARMS2
HTRA1
CFH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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