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Assessing Susceptibility to Age-related Macular Degeneration with Proteomic and Genomic Biomarkers

1 Jun 2009

Abstract excerpt

Age-related macular degeneration (AMD) is a progressive disease and major cause of severe visual loss. Toward the discovery of tools for early identification of AMD susceptibility, we evaluated the combined predictive capability of proteomic and genomic AMD biomarkers. We quantified plasma carboxyethylpyrrole (CEP) oxidative protein modifications and CEP autoantibodies by ELISA in 916 AMD and 488 control donors....

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PMID: 19202148
DOI: 10.1074/mcp.m800453-mcp200

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