Article
Complete characterization of the microRNAome in a patient with acute myeloid leukemia.
Blood - 9 Dec 2010
Ramsingh Giridharan, Koboldt Daniel C, Trissal Maria, Chiappinelli Katherine B, Wylie Todd, Koul Sunita, Chang Li-Wei, Nagarajan Rakesh, Fehniger Todd A, Goodfellow Paul, Magrini Vincent, Wilson Richard K, Ding Li, Ley Timothy J, Mardis Elaine R, Link Daniel C
Abstract excerpt
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and have been implicated in the pathogenesis of cancer. In this study, we applied next generation sequencing techniques to comprehensively assess miRNA expression, identify genetic variants of miRNA genes, and screen for alterations in miRNA binding sites in a patient with acute myeloid leukemia. RNA sequencing of leukemic myeloblasts or...
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