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A microRNA expression signature in infant t(4;11) MLL-AF4+ BCP-ALL uncovers novel therapeutic targets

2023-01-15

Abstract excerpt

<h4>Summary</h4> Infants and children with MLL-AF4+ leukemia have an urgent need for more efficient and less aggressive therapy. In this study, we studied three microRNAs that are downregulated in MLL-AF4+ B-cell precursor acute lymphoblastic leukemia (BCP-ALL): miR-194, miR-99b and miR-125a-5p. When overexpressed, all three microRNAs impaired the survival of MLL-AF4+ leukemic blasts and the maintenance of MLL-AF...

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Literature Corpus work
e5e0a056-9471-5868-b4cf-f5d9aa3b4f42
DOI
10.1101/2023.01.12.523775
Open publication

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