Article
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations.
Proceedings of the National Academy of Sciences of the United States of America - 7 Oct 2008
Li Zejuan, Lu Jun, Sun Miao, Mi Shuangli, Zhang Hao, Luo Roger T, Chen Ping, Wang Yungui, Yan Ming, Qian Zhijian, Neilly Mary Beth, Jin Jie, Zhang Yanming, Bohlander Stefan K, Zhang Dong-Er, Larson Richard A, Le Beau Michelle M, Thirman Michael J, Golub Todd R, Rowley Janet D, Chen Jianjun
Abstract excerpt
MicroRNAs (miRNAs) are postulated to be important regulators in cancers. Here, we report a genome-wide miRNA expression analysis in 52 acute myeloid leukemia (AML) samples with common translocations, including t(8;21)/AML1(RUNX1)-ETO(RUNX1T1), inv(16)/CBFB-MYH11, t(15;17)/PML-RARA, and MLL rearrangements. Distinct miRNA expression patterns were observed for t(15;17), MLL rearrangements, and core-binding factor...
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