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Article

Polymorphisms in the CPB2 gene are maintained by balancing selection and result in haplotype-preferential splicing of exon 7.

Molecular biology and evolution - 1 Aug 2010

Cagliani Rachele, Fumagalli Matteo, Riva Stefania, Pozzoli Uberto, Fracassetti Marco, Bresolin Nereo, Comi Giacomo P, Sironi Manuela

Abstract excerpt

The CPB2 gene encodes thrombin-activatable fibrinolysis inhibitor (TAFI), a hepatically secreted zymogen acting as a molecular link among coagulation, fibrinolysis, and inflammation. Variants in CPB2 have been associated with several human conditions. We resequenced and analyzed the two regions carrying previously known nonsynonimous single-nucleotide polymorphisms (Ala147Thr and Ile325Thr) and variants affecting...

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Identifiers

PMID: 20237223
DOI: 10.1093/molbev/msq082

Genes

CPB2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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