Article
Human F7 sequence is split into three deep clades that are related to FVII plasma levels.
Human genetics - 1 Feb 2006
Sabater-Lleal Maria, Soria José Manuel, Bertranpetit Jaume, Almasy Laura, Blangero John, Fontcuberta Jordi, Calafell Francesc
Abstract excerpt
It is widely accepted that FVII levels are strongly, consistently, and independently related to cardiovascular risk. These levels are influenced by genetic and environmental factors. Among the genetic factors, only a limited number of polymorphisms in the F7 gene have been reported, and they explain only a small proportion of the genetic variability. Recently, we have accomplished the complete dissection of the...
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