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Article

Association of a single nucleotide polymorphism in CPB2 encoding the thrombin-activable fibrinolysis inhibitor (TAF1) with blood pressure.

Clinical genetics - 1 Nov 2001

Koschinsky M L, Boffa M B, Nesheim M E, Zinman B, Hanley A J, Harris S B, Cao H, Hegele R A

Abstract excerpt

Thrombin-activable fibrinolysis inhibitor (TAFI) is a hepatically secreted zymogen, whose substrates include bradykinin. The CPB2 gene encoding TAFI is a candidate gene for blood pressure. A recently identified single nucleotide polymorphism (SNP) in the CPB2 coding region, designated as 1057C >...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11903334
DOI: 10.1034/j.1399-0004.2001.600504.x

Genes

CPB2
TAF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11903334-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of a single nucleotide polymorphism in CPB2 encoding the thrombin-activable fibrinolysis inhibitor (TAF1) with blood pressure.PMID 11903334Read ↗

A Genome-wide Study of Common and Rare Genetic Variants Associated with Circulating Thrombin Activatable Fibrinolysis Inhibitor.Semantic proximity Read ↗

Meta-analysis of TAFI polymorphisms and risk of cardiovascular and cerebrovascular diseases.Semantic proximity Read ↗

Effect of single nucleotide polymorphisms on expression of the gene encoding thrombin-activatable fibrinolysis inhibitor: a functional analysis.Semantic proximity Read ↗

Genetic and biochemical factors associated with variation in blood pressure in a genetic isolate.Semantic proximity Read ↗

A genome-wide exploration suggests an oligogenic model of inheritance for the TAFI activity and its antigen levels.Semantic proximity Read ↗

Fine mapping of quantitative trait nucleotides underlying thrombin-activatable fibrinolysis inhibitor antigen levels by a transethnic study.Semantic proximity Read ↗

Prostasin: a possible candidate gene for human hypertension.Semantic proximity Read ↗

Thrombin activatable fibrinolysis inhibitor gene polymorphisms are associated with antigenic levels in the Asian-Indian population but may not be a risk for stroke.Semantic proximity Read ↗

Significant genetic association of a functional TFPI variant with circulating fibrinogen levels and coronary artery disease.Semantic proximity Read ↗

Polymorphisms in the CPB2 gene are maintained by balancing selection and result in haplotype-preferential splicing of exon 7.Semantic proximity Read ↗

Thrombin-activatable fibrinolysis inhibitor (TAFI) levels and its polymorphism rs3742264 are associated with dyslipidemia in a cohort of Brazilian subjects.Semantic proximity Read ↗

A locus on chromosome 13 influences levels of TAFI antigen in healthy Mexican Americans.Semantic proximity Read ↗

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