Article
The close correlation between 8-hydroxy-2'-deoxyguanosine and epidermal growth factor receptor activating mutation in non-small cell lung cancer.
Human pathology - 1 Jul 2010
Kawahara Akihiko, Azuma Koichi, Hattori Satoshi, Nakashima Kazutaka, Basaki Yuji, Akiba Jun, Takamori Sinzo, Aizawa Hisamichi, Yanagawa Takashi, Izumi Hiroto, Kohno Kimitoshi, Kono Suminori, Kage Masayoshi, Kuwano Michihiko, Ono Mayumi
Abstract excerpt
Patients with non-small cell lung cancer harboring mutations in the epidermal growth factor receptor gene, including delE746-A750 and L858R, are highly sensitive to therapy with epidermal growth factor receptor-targeting drugs, such as gefitinib and erlotinib, in comparison with those harboring wild-type epidermal growth factor receptor. It remains unclear how such epidermal growth factor receptor mutations are...
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