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Article

DNA Repair Activity for Oxidative Damage and Risk of Lung Cancer

2 Sept 2003

Abstract excerpt

BACKGROUND: Although smoking is a major cause of lung cancer, only a proportion of smokers develop lung cancer, suggesting a genetic predisposition in some individuals. Because tobacco smoking is associated with the increased formation of DNA lesions, including those induced from oxidative damage, we investigated whether the activity of the DNA repair enzyme 8-oxoguanine DNA N-glycosylase (OGG), which repairs the...

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PMID: 12953085
DOI: 10.1093/jnci/djg033

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