Article
Detection of Epidermal Growth Factor Receptor Gene Status via a DNA Electrochemical Biosensor Based on Lambda Exonuclease-assisted Signal Amplification.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry - 10 Jun 2020
Weng Xiuhua, Xu Xiongwei, Huang Pinfang, Liu Zhoujie, Liu Ailin, Chen Wei, Lin Xinhua
Abstract excerpt
Based on our previous work, we have constructed a new electrochemical biosensor to detect epidermal growth factor receptor (EGFR) gene mutation, which was a significant therapeutic effect predictor of target drugs for non-small cell lung cancer. In order to lower the detection limit to detect the small amount of EGFR gene status, we have employed lambda exonuclease (λ-Exo) to form a hybridization-digestion cycle....
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