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Article

Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors.

Cancer biology & therapy - 1 Feb 2010

Li Ang, Omura Noriyuki, Hong Seung-Mo, Goggins Michael

Abstract excerpt

DNA methyltransferase I (DNMT1) is the major methyltransferase responsible for methylating DNA and is overexpressed in many cancers. DNMT1 is also a therapeutic target for chemotherapy and chemoprevention. We hypothesized that loss of DNMT1 copy number could result in reduced DNMT1 levels and greater sensitivity to DNMT1 inhibitors. We examined DNMT1 expression in pancreatic cancers by immunohistochemistry and...

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Source

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Identifiers

PMID: 20234167
DOI: 10.4161/cbt.9.4.10750
PMCID: PMC2920347

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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