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Article

Pancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes

3 Jun 2015

Abstract excerpt

DNA methylation is an epigenetic mark associated with regulation of transcription and genome structure. These markers have been investigated in a variety of cancer settings for their utility in differentiating normal tissue from tumor tissue. Here, we examine the direct correlation between DNA methylation and patient survival. We find that changes in the DNA methylation of key pancreatic developmental genes are...

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PMID: 26039411
DOI: 10.1371/journal.pone.0128814

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