Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.

doi:10.1164/rccm.200906-0896OC

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Article

Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program.

American journal of respiratory and critical care medicine - 15 Feb 2010

Moore Wendy C, Meyers Deborah A, Wenzel Sally E, Teague W Gerald, Li Huashi, Li Xingnan, D'Agostino Ralph, Castro Mario, Curran-Everett Douglas, Fitzpatrick Anne M, Gaston Benjamin, Jarjour Nizar N, Sorkness Ronald, Calhoun William J, Chung Kian Fan, Comhair Suzy A A, Dweik Raed A, Israel Elliot, Peters Stephen P, Busse William W, Erzurum Serpil C, Bleecker Eugene R

Abstract excerpt

RATIONALE: The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma. OBJECTIVES: To identify novel asthma phenotypes using an unsupervised hierarchical cluster analysis. METHODS: Reduction of the initial 628 variables to 34 core variables was...

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PMID: 19892860
DOI: 10.1164/rccm.200906-0896OC
PMCID: PMC2822971

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