Article
TGFbeta mediated transition of corneal fibroblasts from a proinflammatory state to a profibrotic state through modulation of histone acetylation.
Journal of cellular physiology - 1 Jul 2010
Zhou Qingjun, Yang Lingling, Wang Yao, Qu Mingli, Chen Peng, Wang Ye, Xie Lixin, Zhao Jing, Wang Yiqiang
Abstract excerpt
Corneal fibroblasts exhibit different phenotypes in different phases of corneal wound healing. In the inflammatory phase, the cells assume a proinflammatory phenotype and produce large amounts of cytokines and chemokines, but in the proliferative and remodeling phases, they adapt a profibrotic state, differentiate into myofibroblasts and increase extracellular matrix protein synthesis, secretion, and deposition....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.