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Article

Stiffness-dependent dynamic effect of inflammation on keratocyte phenotype and differentiation.

Biomedical materials (Bristol, England) - 27 Apr 2023

Chen Jialin, Mo Qingyun, Sheng Renwang, Long Qiuzi, Chen Zhixuan, Liu Chuanquan, Zhang Aini, Luo Yifan, Liu Jia, Zhang Wei

Abstract excerpt

Although extensive studies have evaluated the regulation effect of microenvironment on cell phenotype and cell differentiation, further investigations in the field of the cornea are needed to gain sufficient knowledge for possible clinical translation. This study aims to evaluate the regulation effects of substrate stiffness and inflammation on keratocyte phenotype of corneal fibroblasts, as well as the...

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PMID: 37068490
DOI: 10.1088/1748-605X/accda9

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