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Article

Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition.

American journal of physiology. Lung cellular and molecular physiology - 1 Nov 2009

Guo Weichao, Shan Bin, Klingsberg Ross C, Qin Xiangmei, Lasky Joseph A

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a devastating disease with no known effective pharmacological therapy. The fibroblastic foci of IPF contain activated myofibroblasts that are the major synthesizers of type I collagen. Transforming growth factor (TGF)-beta1 promotes differentiation of fibroblasts into myofibroblasts in vitro and in vivo. In the current study, we investigated the molecular link between...

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Identifiers

PMID: 19700647
DOI: 10.1152/ajplung.00128.2009
PMCID: PMC2777501

Genes

HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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